But the vagiaries of Uefa's seeding system means the Italian champions, who have won the last six Serie A titles, head to Spain to face five-time European champions Barcelona.
The Juventus number ten still has many years of his career ahead of him and has been tipped in some quarters to be a future Ballon d'Or winner once Messi and Real Madrid star Cristiano Ronaldo retire.
"They have lost Bonucci but they remain a very strong, good team", said Valverde on Monday. We were punished for the first error, 30 seconds from half-time, when we didn't close Messi down or foul him. When we play against teams of this level we cannot allow ourselves to switch off. That's the difference.
The 20-year-old came off the bench to set up a late goal for Luis Suarez on his debut as Barca thrashed Espanyol 5-0 on Saturday.
Weakness: The Juventus defence has been significantly weakened by the departure of Leonardo Bonucci.
Barca's start to the season has helped lift some of the gloom around the club raised by losing Neymar to Paris Saint Germain and the failure to sign Coutinho over the summer and the new Barca boss was happy with Tuesday's win.
This season, Juventus gave Dybala the coveted No. 10 shirt - previously worn by the likes of Michel Platini, Roberto Baggio and Alessandro del Piero. "It'll be an intense match", said Valverde. "If we don't give him any space then we can limit what he can do". Instead of Neymar, the Barca has replaced Ousamene Dembele.
Ousmane Dembele, the most expensive signing in Barcelona's history, made his first start for the Catalan club. He has now drifted to 40/1 and bettors have backed off this option after Juventus' lacklustre showing. "You never know what may happen later on".
Giorgio Chiellini has been sidelined with a calf injury since the 1 of September; his return date is not clear. "Meanwhile, Croatian striker Mandzukic is out of the Camp Nou clash after picking up a knock against Chievo that caused a previous tear wound, sustained on international duty against Kosovo, to flare up again".
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